Our laboratory focuses on the fidelity, mechanism, and requirements for DNA replication reprogramming. Reprogramming of DNA replication is a key event in development and differentiation, and is one of several changes required during the induction of pluripotent stem (iPS) cells from adult somatic cells. We use a combination of molecular and cellular approaches including single DNA molecule analysis, high-resolution microarrays and Solexa sequencing to study the role of replication origins and histone modifications in regulating the DNA replication program. For more information please visit the group web site.
We are seeking highly qualified candidates to be involved in studies aimed at elaborating the role of the DNA replication program and it’s reprogramming in the generation of iPS cells. These studies include: (1) examination of reprogramming and regulation of DNA replication in human and mouse embryonic stem (ES) cells and how the replication program changes when ES cells differentiate along various developmental pathways; (2) reprogramming of DNA replication by modification of chromatin structure; (3) telomere replication program of human iPS cells compared to sequential hiPSC-derived developmental stages of neural stem cells and other somatic cells.
These studies are being carried out in the Einstein Center for Human Embryonic Stem Cell Research. We are located in a pleasant, quiet residential area in the northeast corner of New York City with easy access to Manhattan and the suburbs of Westchester County and Connecticut. Affordable University housing is available close to the campus.
Applicants who are highly motivated with a strong background in molecular, stem cell, and/or cancer biology or biochemistry, are encouraged to apply.
Dr. Carl Schildkraut, Department of Cell Biology, Albert Einstein College of Medicine, NY, NY
carl.schildkraut@einstein.yu.edu
Wednesday, July 21, 2010
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